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Oxidative stress and autophagy: the clash between damage and metabolic needs
PDE1B inhibition enhances D1-receptor signaling, ameliorating negative symptoms and cognitive deficits, while PDE10A inhibition modulates D2-receptor activity, potentially alleviating positive symptoms
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We note also that the decrease in the activity of the glutathione-related enzymatic antioxidant system (GST, GR) may play a role in the pathophysiology of seasonal DE, as demonstrated by high seasonal DE in all 3 clusters, especially K1
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