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The study was approved by the Regional Ethical Review Board in Stockholm (registration numbers EPN 2015/57931/2 and 202301601-02)
In an in vitro study, tirzepatide elicited a cAMP response in a human pancreatic -cell line that was significantly higher than that observed for either GLP-1 or GIP alone, indicating a synergistic or additive activation of signaling in pancreatic -cells by GIP and GLP-1 (63)
For instance, if youve reached your goal weight on a GLP-1, a microdose may be appropriate for maintaining your current weight over a long period of time
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