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Genetic mutations leading to obesity in both humans and murine models reveal that defects in the leptin-melanocortin pathway can cause severe obesity as a dominant phenotypic feature

Developing cell-type-specific SIRT1 regulatorsfor example, hepatocyte-targeted molecules using GalNAc ligands or KC-specific nanoparticlesmay allow targeted activation, while selective inhibition in cells such as activated HSCs could also be explored

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