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Patients often experience: Nausea Vomiting Diarrhea Constipation These symptoms can be particularly bothersome and may affect a patients willingness to continue the medication

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doi: 10.1107/S0907444913000061 15 FalonyG.Vieira-SilvaS.RaesJ

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All these factors have a cascading effect and influence the regular cell cycle, whereby inhibition of apoptosis, reduced accumulation of anti-cancer drugs, and overexpression of oncogenes are common

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