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Haffner SM, Lehto S, Rnnemaa T, Pyrl K, Laakso M: Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

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Thus, in patients with type 2 diabetes, combination incretin therapy is poised to provide better glycemic efficacy than treatment with a GLP-1 receptor agonist alone while maintaining a good side-effect profile with respect to avoiding hypoglycemia. As Healio previously reported, top-line data from SURPASS-4, the largest and longest trial of the program to date, also demonstrated that tirzepatide significantly reduced HbA1c and body weight compared with insulin glargine (Lantus, Sanofi) for adults with type 2 diabetes at high cardiovascular risk

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