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Along with the breakdown of antioxidant defenses, there can be dramatic skin membrane lipid peroxidation, triggering ferroptosis, a skin cell death
In animal models, glial cells such as astrocytes and NG2 oligodendrocyte precursor cells can be directly converted into functional neurons in vivo via ectopic expression of neurogenic transcription factors like NeuroD1 and Ascl1
It's not about one being definitively 'better' than the other
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