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Since peptides, proteins, and hormones can directly reach the brain when administered intranasally via transport and diffusion along the olfactory and trigeminal nerves [241], future studies should explore whether intranasal melatonin could be a viable therapeutic option for increasing brain melatonin levels in individuals at risk of developing AD

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In regions with different healthcare reimbursement policies, the cost-effectiveness of liraglutide and dulaglutide can also influence the inclusion of these drugs in the reimbursement lists

Important: Poor gut health can cause methylation issues by inhibiting the uptake of methylfolate into the methionine cycle