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REDEFINE 1's 68-week endpoint for cagrilintide alone was 11.5% (treatment-policy) / 11.8% (trial-product), with the curve visibly flattening around week 52
PIONEER 1 compared oral semaglutide with placebo [76], while PIONEER 24 compared oral semaglutide with the SGLT2i empagliflozin (25 mg once daily), the DPP-4 inhibitor sitagliptin (100 mg once daily), and the subcutaneous GLP-1RA liraglutide (1.8 mg once daily) [38, 39, 61, 62]
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